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NASDAQ: UPB Upstream Bio, Inc. 424B5

Upstream Bio launches at-the-market offering of up to $150M common stock at $8.45/share

Filed March 26, 2026 · ~1 min read

Key Changes

  • high

    Upstream Bio is offering up to $150 million of common stock via an at-the-market program, with shares sold at prevailing market prices.

    The Offering verify on EDGAR →
  • high

    The offering price is $8.45 per share, the last reported sale price on Nasdaq on March 24, 2026.

    The Offering verify on EDGAR →
  • high

    Implied post-offering market capitalization is $608.3 million, based on 71,989,229 shares outstanding after the offering.

    The Offering verify on EDGAR →

3 more material changes behind this preview — plus the full narrative summary, section-by-section diffs against the prior filing, and verbatim quotes with EDGAR citations.

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Figures/quotes linked to EDGAR · Narrative written by AI · Sep 3, 2026 · How we verify