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Risk Profile Improvements

  • Material Weakness (removed) — Prior filing disclosed ongoing material weakness in internal controls (lack of segregation of duties, inadequate system/manual controls); current filing states controls are effective as of December 31, 2025.
NASDAQ: SILO Silo Pharma, Inc. 10-K

Silo Pharma pivots to crypto treasury, delays lead drug IND, terminates key MS license

Filed March 27, 2026 · Period ending December 31, 2025 · Compared to 10-K Mar 28, 2025 · ~2 min read

Key Changes

  • high

    Company launched cryptocurrency treasury strategy in August 2025, deploying $320K into Bitcoin, Ethereum, Solana, and staked tokens. Management now describes the firm as a 'developmental stage biopharmaceutical and cryptocurrency company.'

    Business: Cryptocurrency Treasury Strategy verify on EDGAR →
  • high

    Terminated exclusive UMB license for SPU-16 (multiple sclerosis peptide therapy) and replaced it with a non-renewable option expiring March 31, 2026. Company states it does not intend to extend the option.

    Business: UMB License Termination verify on EDGAR →
  • high

    IND submission for lead PTSD candidate SPC-15 pushed from 2025 to 2026, representing a one-year delay in the regulatory timeline despite completing first GLP tox dosing in March 2025.

    MD&A: SPC-15 Timeline verify on EDGAR →

2 more material changes behind this preview — plus the full narrative summary, section-by-section diffs against the prior filing, and verbatim quotes with EDGAR citations.

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Source-verified from EDGAR · Narrative written by AI · Jun 3, 2026 · How we verify