NASDAQ: AMST

We believe that we have a pathway to deliver AI
solutions impactfully, quickly, and compliantly across this expansive, underserved segment. Adoption by both caregivers and enterprise
partners demonstrates the relevance and commercial fit of our technology. Growth in contracted organizations and end users, alongside
positive market feedback, provides further confidence in the direction we have chosen—even as we remain measured and pragmatic about
future expansion. Significant risks remain for us in the space as we navigate customer, regulatory and user requirements, while continuing
to strive to offer innovative solutions. We face substantial competition from existing players, who have already oversomeovercome these
hurdles. Though we are committed to delivering innovation to a space that we believe is hungry for it, we will also have the additional
work of convincing customers to choose our technology-driven approach.

Our Amesite Engage platform, meanwhile, remains
a performant solution for its user base,, though we are not dedicating resources to its growth.

Overall, we believe that we have consistently
endeavored to provide strong fiscal discipline, launching and scaling innovative products while managing costs and prioritizing efficient
resource allocation. We believe this disciplined approach strengthens our potential to grow responsibly, and ultimately, profitably.

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Our Sales and Marketing Motions

Amesite’s go-to-market strategy for NurseMagic™
is distinctly structured for B2C and B2B audiences, leveraging our growing insights from both segments to build market share, drive recurring
revenue, and establish the brand as a trusted, high-value solution for all individual nurses, and for businesses in post-acute care.

B2C Sales and Marketing

For individual nurses and caregivers, we offer
a free version of NurseMagic™. This approach lowers barriers to adoption and enables us to gather invaluable, real-world feedback
quickly, helping us refine features, tailor language, and build a user community that advocates for the product. Our B2C marketing utilizes
digital outreach, targeted social media campaigns and community engagement to increase awareness and credibility. The app’s everyday
utility and ease-of-use are promoted through user testimonials, while customer support and product updates sustain positive reviews and
word-of-mouth growth. Widespread adoption among practitioners enhances our reputation and provides invaluable reference points as we
approach enterprise buyers.

B2B Sales and Marketing

Our B2B sales effort targets healthcare enterprises
operating in post-acute settings, spanning home health, skilled nursing, hospice, assisted and senior living centers. Our sales motion
is outcome-focused: we identify organizations facing acute staffing and operational pain, then directly connect with decision-makers.
Our B2C solution offers a free version, enabling decision-makers to test the app and quickly validate impact and reduce hesitancy. We
emphasize NurseMagic™’s potential to save time, support regulatory compliance, enhance documentation accuracy, and drive measurable
improvements in staff efficiency and retention. We strive to deploy rapidly, ensuring business continuity and value realization. Feedback
from both administrators and frontline staff informs product development and strengthens our relationships with enterprise customers.

Our disciplined, evidence-based approach in both
segments supports Amesite’s reputation as a partner that delivers real solutions to pressing business challenges, helping drive
strong adoption, build reference customers, and sustain healthy growth, even in complex, compliance-intensive markets.

Our Technology and Pipeline

Amesite’s technology platform is purpose-built
to rapidly deliver high-impact, compliant solutions across healthcare and corporate learning. We power both our NurseMagic™ and
Amesite Engage products from a coordinated infrastructure built for security, flexibility, and speed.

Our core architecture uses modern, best-in-class
languages and frameworks for both client and server-side development, supporting robust, scalable front-end tools. This design gives our
engineering team exceptional agility, simplifying the integration of new functionalities and APIs as soon as they become available. By
leveraging both widely adopted technologies and proprietary models, trained on selectively curated datasets, we aim to deliver meaningful,
real-world improvements for our customers.

Notable milestones include the commercialization
of NurseMagic™ for both B2C and B2B users, the rollout of HIPAA-compliant enterprise workflows, and deployment of features specifically
requested by frontline healthcare professionals. We also invested in our data infrastructure, ensuring continual performance improvement
while maintaining data security and compliance.

We collect information on user behavior and product
use, only with full user consent, to drive product enhancements. Our data practices prioritize security, confidentiality, and compliance
with evolving regulations, especially relevant in complex healthcare contexts.

Agility is a central goal of our R&D culture.
Our team, benefiting from decades of collective experience in technology, endeavors to deliver continuous improvement against stringent,
best-in-class metrics. We launch more than five new features and capabilities per week, prioritizing those that solve urgent user problems
and are directly usable by our customers. All R&D resources are squarely dedicated to delivering tangible improvements in user experience
and operational impact.

Our deployments are designed for simplicity and
scale: NurseMagic™ aims to be fully deployable to every type of employee in an enterprise, requiring no external system integration,
and is administered entirely within the app. Feature sets are intended to be configurable to individual customer needs, allowing organizations
to adapt our solution to their workflows and rapidly realize value.

Our relentless focus on innovation, speed, and
user impact underpins Amesite’s mission to stay ahead of the curve, helping drive customer satisfaction, adoption, and business
performance across rapidly evolving market segments.

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Our Intellectual Property

We have received fourteen U.S. patents (11 utility,
3 design) and currently have one pending U.S. patent applications, including one to cover the artificial intelligence platform, and others
related to security, power consumption, blockchain, design and other technologies, including methods and systems related to learning systems
and methods.

We endeavor to protect our source codes, methodologies,
algorithms, and techniques directed to other aspects of our artificial intelligence learning platform using our trade secret rights. We
have also registered our trademarks at the United States Patent and Trademark Office for AMESITE®, KEEP LEARNING®,
and LEARNING COMMUNITY ENVIRONMENT®, as well as have pending trademark applications for PREACTO™ and NURSEMAGIC℠.
We have also secured domain names, including amesite.com, amesite.co, amesite.net, and others.

Competition

Our focus is on maximizing the impact and reach
of NurseMagic™ in healthcare and offering greater value than our competitors in the healthcare space. At the same time, we retain
the expertise and capability to further develop Amesite Engage or other solutions as market opportunities arise or demand shifts. The
healthcare software market is comprised of several distinct segments, each defined by the capabilities and focus of competing companies:

Electronic Medical Record (EMR)
or Electronic Health Record (EHR) Firms

These established firms deliver comprehensive
platforms deeply integrated across care operations. Their primary strengths lie in robust compliance frameworks, scalability, and breadth
of features.

Mid-Market and Specialized Vendors

These companies offer focused solutions in documentation,
compliance, or operations, often deploying new technologies rapidly.

AI-First Entrants

A newer class of digital health innovators provide
lightweight, AI-driven tools targeting workflow automation, documentation, and user experience. Their products are easy to onboard and
well-received by practitioners, but scaling compliance, security, and ROI claims for system-wide adoption present challenges.

Niche Clinical Tools

Vendors in this category tailor solutions to specific
care settings—such as home health or assisted living—delivering specialized, regulatory-ready features.

NurseMagic™ has been designed to be at the
intersection of these segments, combining rapid deployment, practitioner-driven design, and robust compliance to meet evolving needs in
post-acute care. We believe that our ur adoption rates and enterprise wins suggest our focus on real workflow impact, security, and regulatory
alignment is resonating. Our continued success will depend on maintaining speed, responsiveness, and disciplined execution in an industry
defined by complexity and rapid change.

Government Regulation and Product Approval

Our principal focus is on delivering NurseMagic™
to the healthcare sector, and we are dedicated to maintaining full compliance with all applicable laws and regulations across every market
we serve or may enter. The healthcare industry is subject to extensive regulatory oversight at both the federal and state levels, demanding
strict standards for patient privacy, data security, clinical quality, and marketing practices.

Our solutions target diverse care settings—such
as skilled nursing, assisted living, memory care, home health, and rehabilitation—and are therefore subject to a broad array of
regulatory requirements. These include, but are not limited to, compliance with the Health Insurance Portability and Accountability Act
(HIPAA), the HITECH Act, and relevant standards set by the Centers for Medicare & Medicaid Services (CMS). We also closely monitor
evolving state regulations, such as those governing data privacy, breach notification, record retention, and specific clinical protocols.

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In addition to laws directly governing healthcare
delivery, our activities—including those involving direct-to-consumer offerings—are regulated by federal and state consumer
protection, data privacy, and marketing laws. Oversight by bodies such as the Federal Trade Commission (FTC) and the U.S. Department
of Health and Human Services (HHS) is rigorous, and includes scrutiny of data usage, patient or end-user consent, and representations
made in our product marketing.

Amesite’s business is built on continuous
monitoring of regulatory developments and proactive efforts to ensure all activities—whether relating to our current healthcare
offerings or to further market expansions—are fully compliant with the latest requirements. We recognize that lapses in regulatory
compliance by us or our clients have the potential to result in penalties, legal liability, or restrictions on operations. As such, we
partner closely with our customers and advisors to safeguard ongoing compliance, prepare for regulatory changes, and support all necessary
approvals for the use of our technology.

Sales and Marketing

In FY 2025, Amesite’s sales and marketing
approach centered on high-velocity onboarding, delivery of scalable product tiers, and digital-first brand building. Amesite’s sales
and marketing strategy is crafted to maximize the reach and value of NurseMagic™ in healthcare, while maintaining flexibility to
pursue additional segments as new opportunities emerge. In FY 2025, we streamlined our approach, making it easier for both individuals
and organizations to discover, adopt, and scale NurseMagic™ through self-service onboarding and clear, tiered offerings. We must
continue to refine and improve our strategy and tactics.

NurseMagic™ Offerings and Onboarding

NurseMagic™ is available in multiple subscription tiers to meet the broad spectrum of customer needs—from individual nurses
and small care teams to large healthcare enterprises. Individual users and team leads can initiate a 7-day free trial via a simple, self-purchase
process, with plans that scale based on team size and organizational requirements. For enterprises, we offer both standard and customized
models, allowing for rapid and broad implementation.

Organizations access NurseMagic™ through
a self-service onboarding process, allowing them to rapidly deploy the solution across their teams without the need for preliminary pilot
programs. This model empowers healthcare businesses to quickly realize benefits such as reduced documentation burdens, greater staff efficiency,
and enhanced patient care. Our flexible pricing and robust support, supported by internal estimates of substantial ROI primarily from
time savings, make large-scale adoption possible.

Market Engagement and Brand Development

Our awareness and adoption efforts are rooted in targeted digital marketing, social media engagement, and partnerships with healthcare
influencers. Amesite leverages a growing online community—now exceeding 37,000 followers—to build NurseMagic™’s
reputation and credibility. User testimonials and advocacy from practitioners not only reinforce our brand but also accelerate word-of-mouth
growth and drive further enterprise interest.

Board of Advisors

Dennis Bernard, Chairman of the Board of Advisors

Mr. Bernard is the founder and President of Bernard
Financial Group and Bernard Financial Servicing Group (“BFG”). BFG is the largest commercial mortgage banking firm in Michigan,
financing, on average, over $1.0 billion annually. Mr. Bernard has been involved with over 1,200 commercial real estate financial transactions
totaling over $18.6 billion. Mr. Bernard specializes in both debt and equity placement with commercial lenders and institutional joint
venture participants.

Martha A. Darling, Member

Over the past 22 years, Ms. Darling has held
volunteer leadership roles nationally and in Michigan and has consulted on education policy issues for the National Academy of Sciences
and other non-profit organizations. Prior to moving to Ann Arbor, Ms. Darling was a Senior Program Manager at The Boeing Company in Seattle,
from which she retired in 1998. She joined Boeing in 1987, with assignments in 747 Program Management, Government Affairs and Boeing’s
Corporate Offices, where she supported the chief executive officer and other executives. Previously, she was Vice President for Strategic
Planning at Seattle-First National Bank and then, on loan from Seattle-First, she served as Executive Director of the Washington Business
Roundtable’s Education Study. From 1977 to 1982 she served in Washington, D.C. as White House Fellow and Executive Assistant to
Secretary of the Treasury W. Michael Blumenthal and then as Senior Legislative Aide to U.S. Senator Bill Bradley. She has also served
as Special Assistant to the Governor of Washington, Research Social Scientist at the Battelle Seattle Research Center, and was a free-lance
consultant to the Organization for Economic Cooperation and Development and other international organizations for four years in Paris.

Theodore l. Spencer, Member

Mr. Spencer is Senior Advisor on Admissions Outreach
at the University of Michigan. Prior to September 2014, he was Associate Vice Provost and Executive Director of Undergraduate Admissions.
Before joining Michigan in 1989, he was an Associate Director of Admissions at the United States Air Force Academy. He is a graduate
of the Military Air War College and was one of thirty-five Air Force recruiting commanders in the United States. He is a retired Lieutenant
Colonel in the United States Air Force. Early in his career, he was a salesman for the IBM Corporation in the City of Detroit. Ted has
presented at numerous professional conferences state-wide, nationally and internationally, and has written and published articles on
the college admissions process. He has received numerous awards and was recognized as the Point Man on Diversity Defense for affirmative
action in college admissions. He has previously served as a Trustee for the College Board and on the faculty for the Harvard Summer Institute
on College Admissions. Ted holds a M.S. degree in sociology from Pepperdine University and a B.S. in political science from Tennessee
State University.

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Human Capital Management

General Information About Our Human Capital
Resources

As of June 30, 2025, we have 6 full-time employees
and 2 consultants. We intend to engage consultants in general administration on an as-needed basis. We also intend to engage experts
in operations, finance and general business to advise us in various capacities. None of our employees are covered by a collective bargaining
agreement, and we believe our relationship with our employees is good to excellent.

Our Culture

Amesite’s mission is to empower people
with AI tools. We believe that supporting our team with a wonderful environment supports and powers us to accomplish our goals. Our values
are summarized in our beats-the guideposts for our culture.

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Judgment beats rules

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Measurement beats conjecture

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Humility beats arrogance

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Honesty beats politeness

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Growth beats comfort

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Transparency beats manipulation

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Passion beats indifference

Corporate Information

The Company was incorporated in November 2017.
The Company is Amesite Inc. (Nasdaq: AMST) is a pioneering technology company specializing in the development and marketing of B2C and
B2B AI-driven solutions, including its higher ed platform that offers professional learning. Leveraging its proprietary AI infrastructure,
Amesite offers cutting-edge applications that cater to both individual and professional needs. NurseMagic™, the Company’s
mobile healthcare app, streamlines creation of nursing notes and documentation tasks, enhances patient communication, and offers personalized
guidance to nurses on patient care, medications, and handling challenging workplace situations. The Company’s activities are subject
to significant risks and uncertainties. The Company’s operations are in two segments.

On September 18, 2020, we consummated a reorganizational
merger (the “Reorganization”), pursuant to an Agreement and Plan of Merger (the “Merger Agreement”), dated July
14, 2020, whereby Amesite Inc. (“Amesite Parent”), our former parent corporation, merged with and into us, with our Company
resulting as the surviving entity. In connection with the same, we filed a Certificate of Ownership and Merger with the Secretary of
State of the State of Delaware, and changed our name from “Amesite Operating Company” to “Amesite Inc.” The stockholders
of Amesite Parent approved the Merger Agreement on August 4, 2020. The directors and officers of Amesite Parent became our directors
and officers.

Pursuant to the Merger Agreement, on the Effective
Date, each share of Amesite Parent’s common stock, $0.0001 par value per share, issued and outstanding immediately before the Effective
Date, was converted, on a one-for-one basis, into shares of our common stock. Additionally, each option or warrant to acquire shares
of Amesite Parent outstanding immediately before the Effective Date was converted into and became an equivalent option to acquire shares
of our common stock, upon the same terms and conditions.

Our corporate headquarters are located at 607
Shelby Street, Suite 700 PMB 214, Detroit, Michigan 48226, and our telephone number is (734) 876-8130. We maintain a website at www.amesite.com.
The contents of, or information accessible through, our website is not part of this Annual Report on Form 10-K, and our website address
is included in this document as an inactive textual reference only. We make our filings with the SEC, including our Annual Reports on
Form 10-K, Quarterly Reports on Form 10-Q, Current Reports on Form 8-K and all amendments to those reports, available free of charge
on our website as soon as reasonably practicable after we file such reports with, or furnish such reports to, the SEC. The public may
read and copy the materials we file with the SEC at the SEC’s Public Reference Room at 100 F Street, NE, Washington, D.C. 20549.
The public may also obtain information on the operation of the Public Reference Room by calling the SEC at 1-800-SEC-0330. Additionally,
the SEC maintains an internet site that contains reports, proxy and information statements and other information. The address of the
SEC’s website is www.sec.gov. The information contained in the SEC’s website is not intended to be a part of this filing.

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